Studies on 1-Azabicyclo Compounds. VIII. : Syntheses of Nine-membered Ring Amines from Octahydropyrrocoline
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چکیده
منابع مشابه
Studies on transannulation reactions across a nine-membered ring: the synthesis of natural product-like structures.
A series of diverse natural product-like structures have been synthesised by the use of a number of novel transannulation reactions across a cyclononene ring. Transannular cyclisations through oxygen functionality have generated a number of bicyclo[5.3.1]systems containing bridged cyclic ethers and bicyclo[5.2.2]lactones, as well as a tetrahydrofuran-containing bridged analogue of hexacyclinic ...
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The reactions of 3-phenyl-1-azabicyclo[1.1.0]butane (4) with dimethyl dicyanofumarate ((E)-8) and dimethyl dicyanomaleate ((Z)-8) lead to the same mixture of cisand trans-4-phenyl-1-azabicyclo[2.1.1]hexane 2,3-dicarboxylates (cis-11 and trans-11, resp.; Scheme 3). This result of a formal cycloaddition to the central C-N bond of 4 is interpreted by a stepwise reaction mechanism via a relatively ...
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Three types of small ring compounds (epoxides, aziridines and cyclopropanes) can be synthesized stereoselectively via ylide route. Among them, the stereochemistry of vinyloxiranes, vinylaziridines, cyclopropylesters, amides and ketones can be tuned by the choice of reaction conditions and ylides with varying heteroatoms and ligands. Optically active epoxides and acetylenylaziridines can be prep...
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Indole-substituted oxazolidinones, oxazolones, pyrrolidinone, imidazolidinone and imidazolones were synthesized. Their inhibitory potencies towards protein kinase C and protein kinase A were determined and their in vitro activities against Streptomyces chartreusis, Streptomyces griseus, Bacillus cereus, Candida albicans and Escherichia coli were examined. The inhibition of Streptomyces sporulat...
متن کاملEffect of 14-membered ring macrolide compounds on rat leucocyte chemotaxis and the structure-activity relationships.
significantly by long-term and low-dose treatment of 14memberedring macrolide antibiotics such as erythromycin (EM), clarithromycin (CAM) and roxithromycin (RXM)3'4). Anti-inflammatory mechanisms of macrolide antibiotics include the down-regulation of inflammatory cytokines and lymphocytes. EM and azithromycin (AZM), a 15memberedring macrolide antibiotic that has clinical effect in the treatmen...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1970
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.90.11_1424